The answer is no, not so much as a guess but as a statement. But not in a way that will crush your dreams. Spoiler warning I suppose?
This series isn't something "KyoAni" is coming up with. Euphonium is an adaptation. Not a conservative one with no freedom for the anime's staff, but one that by all means sticks to the novel as a framework. They're not even the ones who turned their relationship into something that could (should?) be constructed as yuri, that's how the author wrote it to begin with. The anime arguably takes it to another level because building characters and relationships through nuanced animation is what many KyoAni members excel at, but that's besides the point. Either way, that faithfulness isn't surprising, since the show exists because enough people at the studio enjoyed the books and went to ask the publisher for the rights. The series will stick to all the major plot events of the novel, and that includes whoever the protagonist ends up (or doesn't, rather) with. If you think that Kumiko ending up in a romantic relationship with Reina would be very doable and shouldn't even be considered a big deal to begin with then... yes, I agree. You can easily switch Reina's ULTIMATELY INCONSEQUENTIAL (that's important) crush for Taki with admiration, and keep escalating her intimate relationship with Kumiko to make them an official couple. Sadly we're still at the point where that would be considered a huge deviation from the source material, since homosexual relationships haven't really been accepted as natural and mundane. It sucks.
Buuuuuut that said, people are treating this as a binary issue where the only options are the rightful yuri ship or HET HELL, when in reality she'll end up with no one. People maliciously kept bringing up a Kumiko x Shuichi scene with no context, not mentioning how that was part of the final collection of shorts and not actually part of the main story. Very few westerners have read the novels so the misinformation is rampant, but my good friend megax (who read what was available even before the anime) has told me a lot about this in private. He strongly felt that the infamous final short might have been an editorial demand, since it really felt /off/. Eupho's a series about adolescence yet it had no romantic conclusion of any sort, even though that's what the broader audiences want (hence why these debates and questions exist to begin with). The "safe" and "normal" closure was getting her together with the male childhood friend, even though the series didn't build up to that. This also sucks.
What does this mean in regards to the anime? Probably nothing. There are 3 novels + that collection of shorts, and we don't even know if the second season of the anime will get to the third volume. And even if it eventually does, it'd still end at a point where Kumiko has no romantic partner. If you want to headcanon that she goes and marries Kumiko 5 minutes after the show ends, go ahead. I will.
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