Mathematics can be considered to be the most efficient tool to get to truth. But you can't be 100% sure of any result even 1+1 =2 is questionable! I once heard about a famous mathematician called Godel and his in-completeness theorem which suggests that you can never get to a complete set of axioms to build mathematics on. Poor Russel and Whitehead spent so much time trying to get to such set of axioms and thought they did in their book "Principia Mathematica" but Godel was like "I'm going to ruin this two men's whole life" xd